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Published Articles

Sunday 18, 2015

Sewidan N, Abu Khalaf Reema, Mohammad H, Hammad W; In Vitro Studies on Selected Jordanian Plants as Dipeptidyl Peptidase-IV Inhibitors for Management of Diabetes Mellitus, Iranian Journal of Pharmaceutical Research, 2019, Accepted.

 

  1. Abu Khalaf Reema, Masalha D, Sabbah D; DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design, and Synthesis, Current Computer-Aided Drug Design, 2019, Ahead of Print.

 

  1. Sabbah D, Ibrahim A, Talib W, Alqaisi K, Sweidan K, Bardaweel S, Abu Sheikha G, Zhong H, Al-Shalabi E, Abu Khalaf Reema,  Mubarak M; Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents, Medicinal Chemistry, 2018, Ahead of Print.

 

  1. Abu Khalaf Reema, Sabbah D, Al-Shalabi E, Al-Sheikh I, Albadawi G, Abu Sheikha G; Synthesis, Structural Characterization and Docking Studies of Sulfamoyl-Phenyl Acid Esters as Dipeptidyl Peptidase-IV Inhibitors, Current Computer-Aided Drug Design, 14 (2), 2018, 142-151.

 

  1. Sabbah D, Al-Tarawneh F, Talib W, Sweidan K, Bardaweel S, Al-Shalabi E, Zhong H, Abu Sheikha G, Abu Khalaf Reema, Mubarak M; Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents, Medicinal Chemistry, 14 (7), 2018, 695 – 708.

 

  1. Abu Sheikha G, Bkhaitan M, Kalloush H, Hamadneh L, Abu Khalaf Reema, Al-Qirim T, Al-Hiari Y; Synthesis of Novel Benzimidazole-2-Carboxamide Derivatives and In Vivo Antihyperlipidemic  Activity Evaluation, Chemical and Pharmaceutical Bulletin, 66 (4), 2018, 423-426.

 

  1. Sabbah D, Hishmah B, Sweidan K, Bardaweel S, AlDamen M, Zhong H, Abu Khalaf Reema, Ibrahim A, Al-Qirim T, Abu Sheikha G,  Mubarak M; Structure-Based Design: Synthesis, X-Ray Crystallography, and Biological Evaluation of N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as Potential PI3Kα Inhibitors, Anti-Cancer Agents in Medicinal Chemistry, 18 (2), 2018, 263-276.

 

  1. Abu Khalaf Reema, Sabbah D, Al-Shalabi E, Bishtawi S, Albadawi G, Abu Sheikha G; Synthesis, biological evaluation and molecular modeling study of substituted benzyl benzamides as CETP inhibitors, Archiv der Pharmazie, 350 (12), 2017, 1-14.

 

  1. Abu Khalaf Reema, Abd El-Aziz H, Sabbah D, Albadawi G, Abu Sheikha G; CETP Inhibitory Activity of Chlorobenzyl Benzamides: QPLD Docking, Pharmacophore Mapping, and  Synthesis, Letters in Drug Design & Discovery, 14 (12), 2017, 1391-1400.

 

  1. Hikmat S, Al-Qirim T, Alkabbani D, Shattat G, Abu Sheikha G, Sabbah D, Abu Khalaf Reema, Al-hiari Y; Synthesis and in vivo anti-hyperlipidemic activity of novel N-benzoylphenyl-2-furamide derivatives in Wistar rats, Tropical Journal of Pharmaceutical Research, 16 (1), 2017, 193-201.

 

  1. Abu Khalaf Reema, Al-Rawashdeh S, Sabbah D, Abu Sheikha G; Molecular Docking and Pharmacophore Modeling Studies of Fluorinated Benzamides as Potential CETP Inhibitors, Medicinal Chemistry, 13 (3), 2017, 239-253.

 

  1. Abu Khalaf Reema; Exploring Natural Products as a Source for Antidiabetic Lead Compounds and Possible Lead Optimization, Current Topics in Medicinal Chemistry, 16 (23), 2016, 2549-2561.

 

  1. Shattat G, Abusheikha G, Al-Qirim T, Huwaitat R, El-Huneidi W, Abu Khalaf Reema, Al-Hiari Y, Jasim S, Hamadneh L;  Novel  Pyrrole Derivatives as Potent lipid-Lowering Agents in Triton-WR-1339-Induced Hyperlipidemic Rats, Latin American Journal of Pharmacy, 34 (6), 2015, 1258-1264.

 

  1. Sabbah D, Saada M, Abu Khalaf Reema, Bardaweel S, Sweidan K, Al-Qirim T, Al-Zughier A, Abdel Halim H, Abu Sheikha G; Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα), Bioorganic & medicinal Chemistry Letters, 25 (16), 2015, 3120-3124.

 

  1. Abu Khalaf Reema, Jarekji Z, Al-Qirim T, Sabbah D, Shattat G; Pharmacophore modeling and molecular docking studies of acridines as potential DPP-IV inhibitors, Canadian Journal of Chemistry, 93 (7), 2015, 721-729.

 

  1. Abu Khalaf Reema, AbdulaAM, Mubarak MS, Taha MO; Tryptophan and thiosemicarbazide derivatives: design, synthesis, and biological evaluation as potential β-D-galactosidase and β-D-glucosidase inhibitors, Medicinal Chemistry Research, 24 (6), 2015, 2529-2550.

 

  1. Abu Khalaf Reema, Abu Sheikha G, Al-Sha’er M, Taha M; Design, Synthesis and Biological Evaluation of N4-Sulfonamido Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors, The Open Medicinal Chemistry Journal, 7, 2013, 39-48.

 

  1. Al-Qirim T, Shattat G, Sweidan K, El-Huneidi W, Abu Sheikha G, Abu Khalaf Reema, Hikmat S; In Vivo Antihyperlipidemic Activity of New Series of N-(Benzoylphenyl) and N-(Acetylphenyl)-1-benzofuran-2-carboxamides in Rats, Archiv der Pharmazie, 345 (5), 2012, 401-406.

 

  1. Abu Khalaf Reema, Abu Sheikha G, Al-Sha’er M, Ghadeer Albadawi, Taha MO; Design, synthesis and biological evaluation of sulfonic acid ester and benzenesulfonamide derivatives as potential CETP inhibitors, Medicinal Chemistry Research, 21 (11), 2012, 3669-3680.

 

  1. Taha MO, Qandil AM, Al-Haraznah T, Abu Khalaf Reema, Zalloum H,Al-Bakri AG; Discovery of New Anti Fungal Leads via Pharmacophore Modeling and QSAR Analysis of Fungal N-Myristoyl Transferase Inhibitors followed by In Silico Screening, Chemical Biology and Drug Design, 78 (3), 2011, 391-407.

 

  1. Abu Khalaf Reema, AbdulaAM, Mubarak MS, Taha MO; Discovery of New β-D-Glucosidase Inhibitors via Pharmacophore Modeling and QSAR Analysis Followed by In Silico Screening, Journal of Molecular Modeling, 17 (3), 2011, 443-464.

 

  1. AbdulaAM, Abu Khalaf Reema, Mubarak MS, Taha MO; Discovery of New β-D-Galactosidase Inhibitors via Pharmacophore Modeling and QSAR Analysis Followed by In Silico Screening, Journal of Computational Chemistry, 32 (3), 2011, 463-482.

 

  1. Abu Sheikha G, Abu Khalaf Reema, Areej Melhem, Ghadeer Albadawi; Design, synthesis, and biological evaluation of new benzylamino methanone based cholesteryl ester transfer protein inhibitors, Molecules, 15 (8), 2010, 5721-5733.

 

  1. Abu Khalaf Reema, Abu Sheikha G, Bustanji Y, Taha MO; Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration, European Journal of Medicinal Chemistry, 45 (4), 2010, 1598-1617.

 

Published Books:

Reema Abu Khalaf, Alhusban A, Al-Shalabi E, Al-Sheikh I, Sabbah D.

Chapter: Isolation and Structure Elucidation of Bioactive Polyphenols,

In Book: Studies in Natural Product Chemistry (Bioactive Natural Products), Volume 63

Editor: Atta-Ur-Rahman, Elsevier Science Publishers – Amsterdam, the Netherlands, 2019.

 

Published Abstracts:

 

  1. Reema Abu Khalaf, Dima Sabbah, Eveen Al-Shalabi, Iyad Al-Sheikh, Ghadeer Albadawi, Ghassan Abu Sheikha; Oral Presentation: Synthesis, Structural Characterization and Docking Studies of Sulfamoyl-Phenyl Acid Esters as Dipeptidyl Peptidase-IV Inhibitors, 4th Pharmaceutical Chemistry Conference, June 27-28 2019, Amsterdam, Netherlands.

 

  1. Ghassan Abu Sheikha, Dima Sabbah, Shaima’ Hasan, Reema Abu Khalaf, Sanaa` Bardaweel, Kamal Sweidan, Eveen Al-Shalabi, Tariq Al-Qirim, Wamidh Talib, Haizhen A. Zhong; Poster Presentation: Phosphatidylinositol 3-Kinase Alpha (PI3Kα) Enzyme in Cancer Progression: Design, Synthesis, and Biological Evaluation of Novel Molecules Targeting the PI3Kα as Anticancer Agents, Stem Cells and Cancer, Gordon Research Conference, March 24-29 2019, Ventura Beach Marriott, Ventura, CA, United States.

 

  1. Nisreen Hamadeh, Dima Sabbah, Reema Abu Khalaf, Wamidh Talib; Oral Presentation: Structure-Based Design: Synthesis and Biological Evaluation of N-Substituted-4-Hydroxy-6-Nitro-2-Quinolone-3-Carboxamides as Potential PI3Kα Inhibitors, ASU-Pharmacy Fourth Symposium “Recent Trends in Postgraduate Research”, January 5-6th 2019, Amman, Jordan.

 

  1. Reema Abu Khalaf, D Sabbah, E  Al-Shalabi, S Bishtawi, G Albadawi, G Abu Sheikha; Oral presentation: Synthesis, biological evaluation and molecular modeling study of  substituted benzyl benzamides as CETP inhibitors, BIT’s 16th Annual Congress of International Drug Discovery Science and Technology  (IDDST), August 16-19, 2018, Boston, USA.

 

  1. Ghassan Abu Sheikha, Haneen AbuZaid, Hanin Kalloush, Suhair Hikmat, Lama Hamadneh, Samah Ata, Dima Sabbah, Majdi Bkhaitan, Reema Abu Khalaf, Ghassan  Shattat, Tariq Al-Qirim, Kamal Sweidan, and Yusuf Al-Hiari; Poster Presentation: Synthesis of Novel Benzimidazole-2-Carboxamide and  Imidazoles-5-Carboxamide Derivatives and In Vivo Antihyperlipidemic Activity Evaluation. Ligand Recognition and Molecular Gating. Gordon Research Conference, March 4-9, 2018, Ventura Beach Marriott, Ventura, CA.

 

  1. Dima Sabbah, Bayan Hishmah, Kamal Sweidan, Sanaa Bardaweel, Murad AlDamen, Haizhen A. Zhong, Reema Abu Khalaf, Ameerah (Hasan Ibrahim), Tariq Al-Qirim, Ghassan Abu Sheikha, Mohammad S. Mubarak; Oral Presentation: Pharmacophore Based-Design of  Phosphoinositide-3-Kinase (PI3Kα) Inhibitors, Al-Zaytoonah University of Jordan and the University of Toledo International Pharmaceutical Conference (ZTIPC 2017) “New Horizons in Pharmaceutical Research”, November 29-30, 2017, Amman, Jordan.

 

  1. Fatima Al-Tarawneh, Dima Sabbah, Wamidh Talib, Kamal Sweidan, Sanaa Bardaweel, Eveen Al-Shalabi, Haizhen A. Zhong, Ghassan Abu Sheikha, Reema Abu Khalaf, Mohammad S. Mubarak; Poster Presentation: Structure-Based Design, Synthesis, and Biological Evaluation of Benzoin Schiff Bases as Potential Antitumor Agents, Al-Zaytoonah University of Jordan and the University of Toledo International Pharmaceutical Conference (ZTIPC 2017) “New Horizons in Pharmaceutical Research”, November 29-30, 2017, Amman, Jordan.

 

  1. Reema Abu Khalaf, Sarah Al-Rawashdeh, Dima Sabbah, Ghassan Abu Sheikha; Oral Presentation: Fluorinated Benzamides: Molecular Docking and Pharmacophore Modeling Studies Targeting CETP Inhibition, BIT’s 15th Annual Congress of International Drug Discovery Science and Technology (IDDST), July 25-27, 2017, Osaka, Japan.

 

  1. Abd El-Aziz H, Reema Abu Khalaf, Sabbah D, Albadawi G, Abu Sheikha G; Poster Presentation: CETP Inhibitory Activity of Chlorobenzyl Benzamides: QPLD Docking, Pharmacophore Mapping, and Synthesis, Drug Discovery & Therapy World Congress, July 10-13, 2017, Boston, MA, USA.

 

  1. Ameerah (Hasan Ibrahim), Bayan Hishmah, Dima Sabbah, Kamal Sweidan, Sanaa Bardaweel, Murad AlDamen, Reema Abu Khalaf, Haizhen A. Zhong, Tariq Al-Qirim, Ghassan Abu Sheikha; Poster Presentation: N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as Potential PI3Kα, ASU-Pharmacy Third Symposium “Recent Trends in Postgraduate Research”, April 15-16, 2017, Amman, Jordan. The Poster is awarded the Third Place in Postgraduate Poster Competition.

 

  1. Ghassan Abu Sheikha, Dima Sabbah, Bayan Hishmah, Kamal Sweidan, Sanaa Bardaweel, Murad AlDamen, Haizhen A. Zhong, Ameerah (Hasan Ibrahim), Reema Abu Khalaf, Tariq Al-Qirim; Poster Presentation: Structure-Based Drug Design, Synthesis, X-ray Crystallography, and Biological Evaluation of N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as PI3Kα Inhibitors, Mammalian DNA Repair, Gordon Research Conference: Frontiers of Mammalian Genomic Stability in Human Health, February 19-24, 2017, Ventura, CA, USA.

 

  1. Dima Sabbah, Musaab Saada, Reema Abu Khalaf, Sanaa Bardaweel, Kamal Sweidan, Tariq Al-Qirim, Amani Al-Zughier, Heba Abdel Halim, Ghassan Abu Sheikha, Poster Presentation: Structure-Based Drug Design, Synthesis, and Biological Evaluation of Benzoin Analogues as  otential PI3Kα Inhibitors, The University of Jordan School of  Pharmacy, The 4th international Conference & the 2nd Conference of the Association of Faculties of Pharmacy at Jordanian Universities” Excellence in Pharmacy Education & Research: A Quality Approach”, October 25-27, 2016, Amman, Jordan.

 

  1. Musaab Saada, Dima Sabbah, Reema Abu Khalaf, Sanaa Bardaweel, Kamal Sweidan, Tariq Al-Qirim, Amani Al-Zughier, Heba Abdel Halim, Ghassan Abu Sheikha; Poster Presentation: Structure-Based Drug Design, Synthesis, and Biological Evaluation of Novel Benzoin Derivatives as anticancer agents. ASU-Pharmacy Second Symposium ”Recent Trends in Postgraduate Research”, December 5-6, 2015, Amman, Jordan.

 

  1. Reema Abu Khalaf, Ghassan Abu Sheikha; Oral Presentation:  Synthesis and Biological Evaluation of Substituted Fluorinated Benzylamino Benzamides as Potential CETP Inhibitors, Al-Zaytoonah University of Jordan and the University of Toledo International Pharmaceutical Conference (ZTIPC 2015) “Frontiers in the pharmaceutical sciences and pharmacy practice: A global perspective”, October 21-23, 2015, Amman, Jordan.

 

  1. Dima Sabbah, Musaab Saada, Reema Abu Khalaf, Sanaa Bardaweel, Kamal Sweidan, Tariq Al-Qirim, Amani Al-Zughier, Heba Abdel Halim, Ghassan Abu Sheikha; Oral Presentation:  From Hit to Lead: Structure-Based Drug Design, Synthesis, and Biological Evaluation of Novel Benzoin Derivatives as PI3Kα Inhibitors, Al-Zaytoonah University of Jordan and the University of Toledo International Pharmaceutical Conference (ZTIPC 2015) “Frontiers in the pharmaceutical sciences and pharmacy practice: A global perspective”, October 21-23, 2015, Amman, Jordan.

 

  1. Ghassan Abu Sheikha, Dima Sabbah, Reema Abu Khalaf, Tariq Al-Qirim, Sanaa Bardaweel; Poster Presentation: Design, Synthesis and Biological Evaluation of Novel PI3K Alpha Inhibitors with Potential Anti-Cancer Activity, Computer Aided Drug Design: New Frontiers in computer-Aided Drug Design, July 19-24, 2015, VT, USA.

 

  1. Reema Abu Khalaf, Ghassan Abu Sheikha; Oral Presentation: Potential CETP and DPP-IV Inhibitors: Design, Synthesis and Biological Evaluation, Bilateral research workshop between Faculty of Pharmacy, Al-Zaytoonah University of Jordan, and Faculty of Pharmacy, University of Szeged, Hungary, October 21, 2014, Amman, Jordan.

 

  1. Ghassan Abu Sheikha, Reema Abu Khalaf, Dima Sabbah; Poster Presentation: Design, Synthesis, and Biological Evaluation of a New Series of Potential CETP Inhibitors, Ligand Recognition & Molecular Gating: Structure and Dynamics of Ion Channels, G-Protein Coupled Receptors, and Solute Transporters, March 23-28, 2014, Ventura, CA, USA.

 

  1. Ghassan Abu Sheikha, Reema Abu Khalaf; Poster Presentation, FloHet-2013 Florida Heterocyclic and Synthetic Conference, March 3-6, 2013, Gainesville, Florida, USA.

 

  1. Ghassan Abu Sheikha, Reema Abu Khalaf, Mahmoud Al-Sha’er, Ghadeer Albadawi, Mutasem Taha; Poster Presentation: Design, synthesis and biological evaluation of aryl-succinamic, phthalamic, acrylic and acetic acid derivatives as potential DPP IV inhibitors, International Symposia on Advancing the Chemical Sciences- Challenges in Organic Chemistry and Chemical Biology (ISACS7), June 12-15, 2012, Edinburgh, UK.

 

  1. Reema Abu Khalaf; Oral Presentation: Design, Synthesis and Biological Evaluation of Sulfonic Acid Ester and Benzenesulfonamide Derivatives as Potential CETP Inhibitors, The International Conference of Young Chemists (ICYC), April 8-10, 2012, held  at University of Jordan, Amman, Jordan.

 

  1. Reema Abu Khalaf; Oral Presentation: Discovery of New CETP Inhibitors via Ligand-Based Pharmacophore Modeling and QSAR Analysis and Subsequent Hit Optimization, The Jordanian International Pharmaceutical Conference 2008 (JIPC), October 15-17, 2008, held at Al-Zaytoonah University of Jordan, Amman, Jordan.

 

  1. Reema Abu Khalaf; Oral Presentation: The Synthesis and Microbiological Evaluation of Some Novel Derivatives of Some Natural and Synthetic Polymers, The Jordanian International Pharmaceutical Conference 2006 (JIPC), November 15-17, 2006, held at Al-Zaytoonah University of Jordan, Amman, Jordan.

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